How to Bet Patriots vs. Colts Saturday Night Football: Best NFL Betting Picks & Props Tonight

It’s the first Saturday NFL game of the year, and we get arguably two of the best teams in the AFC fighting it out in primetime, The Week 15 Saturday Night Football matchup has the New England Patriots vs. Indianapolis Colts. Let’s take a look at the best Patriots vs. Colts NFL betting picks for the Saturday Night Football game using the Awesemo OddsShopper.

NFL Best Bets & Odds: Week 15 Saturday Night Football

Indianapolis Colts vs. New England Patriots

Date: Saturday, Dec.18, 2021
Time: 8:20 p.m. EST
Venue: Lucas Oil Stadium — Indianapolis, In.
Coverage: NFL Network

Colts vs. Patriots Betting NFL Picks + Odds Shopping

Using Awesemo’s OddsShopper tool, we can easily compare the NFL odds for Cowboys vs. Saints betting across the major sportsbooks. Make sure to check out the OddsShopper tool yourself to get the most up-to-date odds.

Colts vs. Patriots NFL Betting Trends

  • Indianapolis is 8-5 against the spread this season.
  • The over is 8-5 for the Colts this season.
  • New England is 9-4 against the spread this season.
  • The under is 7-6 for the Patriots this season..

Colts vs. Patriots Betting Stats

  • Indianapolis is averaging 28.5 points per game this season (No. 3 in the NFL).
  • The Colts are allowing 21.8 points per game this season (T-No. 9 in the NFL).
  • New England is averaging 26.9 points per game this season (No. 10 in the NFL).
  • The Patriots are allowing 15.4 points per game this season (No. 1 in the NFL).

Colts vs. Patriots Best Player Props

Rhamondre Stevenson – New England Patriots RB Over 67.5 Rush Yards (SugarHouse -110)

Over the last five weeks Stevenson has handled an average of 15 carries producing 71 rushing yards per game. He has pushed over 67.5 rush yards in three of the last four games and feels like a phenomenal option to repeat that success Saturday night. The Colts’ defense hasn’t contained opposing running backs as of late, allowing 5.4 yards per rush attempt over the last three games. Stevenson is in line for a heavy workload following Damien Harris’ inactive status and should see a majority of the Patriots carries after taking 55% of snaps in Harris’ only absence this season. In Week 10 against the Cleveland Browns, Stevenson took 20 carries and four receptions for 114 total yards and two touchdowns. He’s displayed the ability to be an outright RB1 and Bill Belichick appears to be trusting him more and more each week. 

T.Y. Hilton – Indianapolis Colts WR: Over 25.5 Receiving Yards (Caesars +105)

Hilton has had two of his last three seasons detailed by injury but returned to a Colts wide receiver corps desperate for talent. He has seen between 41-61% of snaps over the last four weeks and produced over 22 yards in three consecutive weeks. Although Hilton has only been active for six games this season, he has seen an average of 3.8 targets per game and has the potential to provide Carson Wentz a reliable option outside of Michael Pittman. Bill Belichick typically takes away the opposing team’s top option, which could open up additional targets for the veteran out of Florida International. New England ranks second overall allowing 5.9 yards per pass attempt to opponents but Awesemo is projecting 39.3 receiving yards, which yields an expected win of 66%, the highest on the slate. An expected ROI of 24% is the second-best in this matchup and offers the safest bet out of the Indianapolis pass-catchers. 


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Jakobi Meyers – New England WR: Over 43.5 Receiving Yards (Caesars +110) 

Indianapolis presents a difficult pass defense but Meyers has gone over 43.5 yards in 8-of-13 games this season. He is averaging 47.8 yards receiving per game despite seeing zero targets in their last game against the Buffalo Bills. He leads the Patriots in targets (90) and commands a target share of 23.6%. Aligned in the slot the 11th-most in the NFL (50.3%) projects a matchup with Kenny Moore, who has allowed over 50 yards receiving to Jamison Crowder, A.J. Brown, Mohamed Sanu and Cooper Kupp this season. His air yards share (30.5%) is also the highest in New England and top 25 at the position and with 68.7 air yards per game has plenty of opportunity to hit the over. This prop’s expected ROI of 27% is the highest on the slate and with Awesemo projecting 58.6 receiving yards holds an expected win of 60%. 

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