NFL Sunday caps off with a Sunday Night Football matchup that is considered a “must-win” for both teams despite it only being Week 7 of the season. The Indianapolis Colts will travel to take on the San Francisco 49ers, who are fresh off their bye. The following Colts vs. 49ers NFL betting picks preview will provide the current odds, betting trends, and best NFL bets for the Week 7 Sunday Night Football matchup.
NFL Best Bets & Odds: Week 7 Thursday Night Football
Indianapolis Colts vs. San Francisco 49ers
Date: Sunday, October 24, 2021
Time: 8:20 p.m. EST
Venue: Levi’s Stadium — Santa Clara, Calif.
Coverage: NBC
After losing their first three games of the season, the Colts have been more competitive the past three weeks. They have totaled two wins and an overtime loss over this span, though the wins have come against the Dolphins and Texans, while the overtime loss needed a massive collapse on their end to even go to extra time. Carson Wentz is getting healthier, while the rest of the team is not. T.Y. Hilton is out once again, and the defense has also suffered some key injuries that will be tough to overcome.
The 49ers are fresh off their bye week, and they are 3-0 against the spread following a bye since 2019. Jimmy Garoppolo is back at quarterback, though George Kittle is still out. However, the backfield is getting healthier, which should take some pressure off the passing game. Defensively they live and die by their pass rush, which has not been as elite as seasons past. Fred Warner is a stud in the middle, but he cannot make every play, which is exactly what is needed for this defense to be considered scary.
Colts vs. 49ers Betting NFL Picks + Odds Shopping
Using Awesemo’s OddsShopper tool, we can easily compare the NFL odds for Colts vs. 49ers betting across the major sportsbooks. Make sure to check out the OddsShopper tool yourself to get the most up-to-date odds.
Colts vs. 49ers NFL Betting Trends
- Indianapolis is 4-2 against the spread this season.
- The Over is 3-3 for the Colts this season.
- San Francisco is 1-4 against the spread this season.
- The Over is 2-3 for the 49ers this season.
Colts vs. 49ers Betting Stats
- Indianapolis is averaging 23.2 points per game this season (No. 19 in the NFL).
- Indianapolis is surrendering 21.8 points per game this season (No. 11 in the NFL).
- San Francisco is averaging 23.4 points per game this season (No. 17 in the NFL).
- San Francisco is surrendering 23.8 points per game this season (No. 16 in the NFL).
Colts vs. 49ers NFL Best Bet
We are using the new Awesemo NFL Betting Model to figure out what the best bet for Sunday Night Football is tonight. According to the model, betting the Colts moneyline is the clear best bet to place, giving it a 6.6% ROI, which is the only positive game bet. Due to the odds, the model does not give a positive ROI to betting the 49ers. However, it does give the 49ers a 62% to win the game still, with an expected spread of 3.3 points.
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