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How to Bet 49ers vs. Titans Week 16 Thursday Night Football

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Thursday Night Football for Week 16 features two teams fighting to make the playoffs. While the San Francisco 49ers are surging and claiming one of the wild card spots as their own, the Tennessee Titans are limping down the homestretch and desperately trying to hold onto their playoff spot. Needless to say, this is an important game for both teams, making it intriguing from an NFL betting perspective. The following 49ers vs. Titans NFL betting picks preview will provide the current odds, betting trends, and best NFL bets for the Week 16 Thursday Night Football matchup.

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NFL Best Bets & Odds: Week 16 Thursday Night Football

San Francisco 49ers vs. Tennessee Titans
Date: Thursday, Dec. 23, 2021
Time: 8:20 p.m. EST
Venue: Nissan Stadium — Nashville, Tenn.
Coverage: FOX/NFL Network

The 49ers are rolling, winning five of their past six games. This has them currently in the sixth seed of the NFC, behind two other teams in their own division. With another tough game against the Rams the final game of the season, the 49ers would love to win their next two games and hopefully lock up a playoff spot by then. The team is getting healthier, George Kittle is looking unstoppable, and the defense is making a lot of noise. They have averaged four sacks over per game over their last three.

The Titans have a one-game lead in their division over the Indianapolis Colts, but they are stumbling down the homestretch of the season. They have lost three of their past four games, with their only win coming against Jacksonville. The Titans have a chance to get receiver A.J. Brown back this week, and Julio Jones seems like he may play through yet another hamstring injury. However, this team still looks out of sync without Derrick Henry running 20-plus times. The defense is also playing better than their talent level states, but the secondary can be exposed by competent teams, as the 49ers are.

49ers vs. Titans Betting NFL Picks + Odds Shopping

Using Awesemo’s OddsShopper tool, we can easily compare the NFL odds for 49ers vs. Titans betting across the major sportsbooks. Make sure to check out the OddsShopper tool yourself to get the most up-to-date odds.


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49ers vs. Titans NFL Betting Trends

  • San Francisco is 7-7 against the spread this season.
  • The over is 7-7 for the 49ers this season.
  • Tennessee is 8-6 against the spread this season.
  • The over is 7-7 for the Titans this season.

49ers vs. Titans Betting Stats

  • San Francisco is averaging 25.7 points per game this season (No. 13 in the NFL).
  • San Francisco is surrendering 22.4 points per game this season (T-No. 18 in the NFL).
  • Tennessee is averaging 24.1 points per game this season (No. 15 in the NFL).
  • Tennessee is surrendering 22.1 points per game this season (No. 16 in the NFL).

49ers vs. Titans NFL Best Bet

We are using the new Awesemo OddsShopper Tool to figure out what the best bet for Thursday Night Football is tonight. According to the tool, betting the 49ers moneyline is the most likely bet to hit, giving them a 54% chance to win. While the expected ROI for this bet may be lower than others, it is tough to bet the team more likely to win. They are also the more complete team and have been playing better than the Titans have. Look for the 49ers to pass a bit more tonight, exploiting the weak cornerbacks for Tennessee. This will be their key to victory.

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Best Bet: 49ers Moneyline


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Zach Brunner is the founder of FlurrySports and a featured sports betting and fantasy sports expert for numerous outlets. With an education in business, coaching and history education, he has taken a little bit from all of his experiences to give him a well-rounded, unique point of view in the sports industry. Follow him on Twitter @FantasyFlurry to keep up with other things he is doing.

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