Tonight on Thursday Night Football, there are two teams fighting to stay in the playoffs of their respective conferences, with the San Francisco 49ers and Tennessee Titans facing off. Both teams have been trending in different directions recently. However, anything can happen on a short week of preparation. Let’s take a look at the best 49ers vs. Titans NFL betting picks for the Week 16 Thursday Night Football game using the Awesemo OddsShopper.
NFL Best Bets for Week 16 Thursday Night Football
San Francisco 49ers vs. Tennessee Titans
Date: Thursday, Dec. 23, 2021
Time: 8:20 p.m. EST
Venue: Nissan Stadium — Nashville, Tenn.
Coverage: FOX/NFL Network
49ers vs. Titans NFL Betting Picks + Odds Shopping
Finding the most profitable NFL betting picks has never been easier. The newly updated OddsShopper is like the Amazon of sports betting. Simply filter, sort the page and find the NFL best bets within seconds.
Brandon Aiyuk Under 4.5 Receptions (-170, PointsBet)
As seen on OddsShopper, sorting the player props for this game by the expected win percentage brings this prop to the top. The tool gives the under on this Brandon Aiyuk receptions prop a 76% chance to hit and an expected ROI of 16%. The tool also projects Aiyuk for 3.3 receptions. Aiyuk has picked up his receiving production after his slow start. Part of this success has been Deebo Samuel playing more out of the backfield, but that should happen less tonight. Aiyuk has also totaled over 4.5 receptions just once over his past four games anyways. He is not a high-volume receiver.
Jimmy Garoppolo Over 235.5 Yards Passing (-110, FanDuel)
While Aiyuk may not get five receptions, it does not mean Jimmy Garoppolo will not be passing the ball. The 49ers have been willing to throw the ball when they face teams with good run defenses. That is exactly what they will see in their matchup against the Titans, with Tennessee allowing only 3.9 yards per carry. Garoppolo will be passing against a suspect secondary, and he has passed for over 290 yards in three of his last four road games, with the one failed attempt being a blowout against the Jaguars. OddsShopper projects Garoppolo for 250.5 yards passing tonight, giving this prop a 55% chance to hit the over and a 4% ROI.
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Deebo Samuel Over 44.5 Yards Receiving (-118, SugarHouse)
Deebo Samuel has played 43 snaps out of the backfield over his past five games. While he should still see some snaps there, it is clear he will make a larger impact split out tonight. As stated above, the run defense for Tennessee is good. Their cornerbacks, however, are not. They have allowed the second-most yards receiving to wide receivers this season, at 189.6 per game. Samuel’s increased usage out of the backfield helps keep this prop low. However, he is coming off a 60-yard receiving day, and he should have another high total tonight. OddsShopper projects Samuel for 68.5 yards receiving tonight, giving this prop a 73% chance to hit the over and a 34% ROI.
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